Leuprolide

also known as leuprorelin, Lupron

approved hormone reproductiveendocrine sequence not characterised

87 heavy atoms · 176 bonds · drag to pan, scroll to zoom C59N16O12

Skeletal structure drawn from the computed atomic coordinates in PubChem CID 657181. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.

Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.

Sequence

Primary structure not characterised in the public records this index draws on. Nothing is shown rather than something invented.

A GnRH analogue with pyroglutamate at the N-terminus and D-leucine at position 6.

Molecular data

Chemical fields come from the PubChem compound record; computed values are derived from the sequence shown above.
molecular formula	C59H84N16O12
molecular weight	1209.4 Da (PubChem)
computed backbone mass	not characterised
length	not characterised
net charge (pH 7.4)	not characterised
mean hydropathy	not characterised
half-life	not characterised
delivery route	subcutaneous, intramuscular
PubChem CID	657181
PDB	not characterised
UniProt parent	not characterised

Mechanism

GnRH receptor agonist; continuous exposure downregulates the receptor and suppresses gonadotropins.

Reported targets: GnRHR

Experimental structure

No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.

Reported effects

Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.

Reported observations and the corpus they are drawn from.
reported outcome	where it appears
gonadotropin suppression	Pulmonary alveolar proteinosis diagnosed during leuprorelin acetate therapy … BMC pulmonary medicine 2026
oncology outcomes in trials	GnRH Agonists and Antagonists in IVF/ICSI Cycles of PCOS Women: A Network Me… Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2026

Registered trials

Records from ClinicalTrials.gov. Listed for reference — this project sponsors no trial and is not involved in any of them.
NCT	title	status	phase
NCT04500743	Role of Suppression of Endometriosis With Progestins Before IVF-ET	COMPLETED	NA
NCT02678520	Clinical Trial Comparing 3-D RT vs. IMRT in Post- Prostatectomy Prostate Cancer Patients	WITHDRAWN	PHASE2
NCT01320735	Observational Program to Assess Use of Intermittent Adjuvant Deprivation Therapy With Leupro	COMPLETED	—
NCT02903368	Neoadjuvant And Adjuvant Abiraterone Acetate + Apalutamide Prostate Cancer Undergoing Prosta	COMPLETED	PHASE2
NCT01081873	Study to Document Treatment Patterns and to Evaluate Leuprolide and Alternative Therapeutic	COMPLETED	—

Literature (8)

Pulmonary alveolar proteinosis diagnosed during leuprorelin acetate therapy for ovarian endometrioma: a case report — BMC pulmonary medicine 2026