Galanin

abstract not reproduced — this record is not open-access, so it is linked rather than copied.

publisher record ↗ · PMID 42614515 · DOI 10.3389/fphar.2026.1916071

abstract not reproduced — this record is not open-access, so it is linked rather than copied.

publisher record ↗ · PMID 42573161 · DOI 10.1002/edm2.70303

abstract not reproduced — this record is not open-access, so it is linked rather than copied.

publisher record ↗ · PMID 42414566 · DOI 10.1038/s41386-026-02490-3

Galanin-expressing neurons in the ventrolateral preoptic area (VLPOgalanin) are active during sleep and play an important role in regulating non-rapid eye movement (NREM) sleep. It is generally believed that VLPOgalanin neurons promote sleep via inhibitory actions in arousal-promoting regions of the brain. Histaminergic neurons are a population of wake-active neurons that receive strong projections from the sleep-active VLPOgalanin neurons. However, the ability of galanin to influence the activity of histaminergic neurons has received limited attention. Here, using whole-cell patch-clamp electrophysiological recordings from genetically identified histaminergic neurons in male mice, we explore the mechanisms by which galanin influences histaminergic neuron electrical excitability. Our results reveal that galanin is a powerful inhibitor of histaminergic neuron activity and demonstrate that…

open access ↗ · PMID 41651655 · DOI 10.1523/eneuro.0420-25.2026

IntroductionChronic pain is a major unmet medical need, with current treatments often providing limited relief. The neuropeptide galanin, acting through GalR1-3 receptors, has been implicated in pain modulation. Although galanin analogues are typically administered intrathecally, emerging evidence suggests that peptides can cross the blood-brain barrier. We hypothesized that systemic administration of the biologically active fragment galanin (1-16) could attenuate neuropathic pain.ObjectivesTo evaluate whether intravenous galanin (1-16) reduces pain-like behaviors in a rat model of neuropathic pain and to compare its effects when using a selective GalR1 agonist.MethodsMale Sprague-Dawley rats underwent spared nerve injury. Animals received intravenous galanin (1-16), M617 (selective GalR1), or vehicle. Mechanical and cold allodynia were assessed using von Frey filaments and acetone testi…

open access ↗ · PMID 41822106 · DOI 10.1097/pr9.0000000000001422

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publisher record ↗ · PMID 42269375 · DOI 10.1016/j.npep.2026.102634

The G protein-coupled galanin receptors include three different subtypes: galanin receptor 1, 2 and 3 (GalR1, GalR2, GalR3). The neuropeptide galanin is the principal natural agonist of the galanin receptors, the so-called galaninergic system. Galanin-like peptide and spexin have also been identified as natural ligands of the galanin receptors. Galanin receptors are widely expressed in the brain; however, they can be found in other tissues, such as the skeletal muscle, the heart, and the gastrointestinal tract. The galaninergic system regulates diverse biological processes, including feeding behavior, neuroprotection, learning, memory, cardiovascular and renal function, and nociception. Its dysregulation is associated with various diseases, such as Alzheimer's disease, diabetes mellitus, epilepsy, depression, and cancer. The stimulation of GalR1 and GalR3 leads to the Gαi/o-type G protei…

open access ↗ · PMID 41750307 · DOI 10.3390/biom16020236

abstract not reproduced — this record is not open-access, so it is linked rather than copied.

publisher record ↗ · PMID 41831549 · DOI 10.1016/j.expneurol.2026.115711