database / hormone
Angiotensin II
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 172198. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
DRVYIHPF
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
- hydrophobic
- positive
- negative
- polar
- aromatic
- glycine
- proline
- cysteine
Computed backbone mass 1046.19 Da agrees with PubChem's reported 1046.2 Da (Δ 0.01 Da). Two independent sources agree on the primary structure.
Molecular data
| molecular formula | C50H71N13O12 |
|---|---|
| molecular weight | 1046.2 Da (PubChem) |
| computed backbone mass | 1046.19 Da |
| length | 8 residues |
| net charge (pH 7.4) | 0 |
| mean hydropathy | -0.33 |
| half-life | not characterised |
| delivery route | intravenous |
| PubChem CID | 172198 |
| PDB | not characterised |
| UniProt parent | P01019 |
Mechanism
AT1/AT2 receptor agonist; the effector peptide of the renin-angiotensin system.
Reported targets: AT1R AT2R
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Position in the parent protein
MAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDP…
Parent sequence from UniProt P01019. Produced from angiotensin I by ACE cleavage.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| vasoconstriction | Early hemodynamic response to angiotensin II defines a prognostic phenotype … Journal of critical care 2026 |
| aldosterone release | Effects of esaxerenone add-on therapy versus angiotensin II receptor blocker… Journal of diabetes investigation 2026 |
Registered trials
| NCT | title | status | phase |
|---|---|---|---|
| NCT04715568 | Secondhand Tobacco Smoke and Cardiovascular Disease | RECRUITING | PHASE4 |
| NCT04331574 | Renin-Angiotensin System Inhibitors and COVID-19 | UNKNOWN | — |
| NCT00528385 | Optimalization of Nephroprotection Using Agents Inhibiting Renin-Angiotensin-Aldosterone Sys | COMPLETED | NA |
| NCT02648243 | Impact of a Pharmacist-delivered Discharge and Follow-up Intervention for Patients With Acut | COMPLETED | NA |
| NCT01377285 | Renoprotection by Pentoxifylline and Angiotensin Receptor Blocker in Chronic Kidney Disease | UNKNOWN | PHASE4 |
Literature (8)
Early hemodynamic response to angiotensin II defines a prognostic phenotype in bloodstream infection-associated septic shock — Journal of critical care 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42594819 · DOI 10.1016/j.jcrc.2026.155708
Effects of esaxerenone add-on therapy versus angiotensin II receptor blocker dose escalation on albuminuria and blood pressure in hypertensive patients with type 2 diabetes: An exploratory randomized study — Journal of diabetes investigation 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42555195 · DOI 10.1111/jdi.70412
Angiotensin II in the treatment of distributive shock and identification of clinical profiles with greater therapeutic benefit — Revista espanola de anestesiologia y reanimacion 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42061711 · DOI 10.1016/j.redare.2026.502116
The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter — Current opinion in nephrology and hypertension 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42261750 · DOI 10.1097/mnh.0000000000001203
Angiotensin II and angiotensin-(1-7) neurotransmissions in the medial amygdala differently control cardiovascular and anxiogenic-like responses to stress in rats — Journal of psychopharmacology (Oxford, England) 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42343879 · DOI 10.1177/02698811261453873
Angiotensin-(1-7) suppresses pyroptosis in cerebral endothelium to decrease blood-brain barrier permeability and cognitive impairments in sepsis — The Journal of international medical research 2026
ObjectiveThis study aimed to explore the influence of the angiotensin-(1-7)/Mas receptor and angiotensin II/angiotensin II type 1 receptor pathways on pyroptosis during sepsis and their subsequent effects on cognitive function.MethodsAdult C57BL/6 mice were subjected to cecal ligation and puncture to induce sepsis. Brain microvascular endothelial cells were treated with angiotensin II and angiotensin-(1-7) to evaluate their impact on pyroptotic processes. Cognitive performance was assessed using the Morris water maze method, and blood-brain barrier permeability was quantified using Evans blue staining.ResultsCompared with the sham group, sepsis induced sustained activation of the angiotensin II/angiotensin II type 1 receptor pathway, whereas the angiotensin-(1-7)/Mas receptor pathway was progressively suppressed. Genetic ablation of cysteine-dependent aspartate protease-1 significantly a…
open access ↗ · PMID 42055817 · DOI 10.1177/03000605261437974
Angiotensin-converting enzyme inhibitors show an edge over angiotensin II receptor blockers in cardiovascular outcomes — European heart journal open 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42524189 · DOI 10.1093/ehjopen/oeag118
Angiotensin II Receptor Signaling in the Hypothalamic-Pituitary-Adrenal Axis and Spleen After Spinal Cord Injury Depends on the Sympathetic Innervation Integrity — Cellular and molecular neurobiology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42250115 · DOI 10.1007/s10571-026-01760-4
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