database / longevity

Vilon

also known as Lys-Glu, KE peptide

preclinical longevity immune no independent mass to check against

Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.

Sequence

Lys-Glu

hydrophobic
positive
negative
polar
aromatic
glycine
proline
cysteine

No independent molecular weight was available to check the sequence against.

Molecular data

Chemical fields come from the PubChem compound record; computed values are derived from the sequence shown above.
molecular formula	not characterised
molecular weight	275.3 Da (computed from sequence)
computed backbone mass	275.3 Da
length	2 residues
net charge (pH 7.4)	0
mean hydropathy	-3.7
half-life	not characterised
delivery route	not characterised
PubChem CID	not characterised
PDB	not characterised
UniProt parent	not characterised

Mechanism

Short regulatory dipeptide from the Khavinson peptide series, studied for immune and gene-expression effects.

Reported targets: not established

Experimental structure

No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.

Reported effects

Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.

Reported observations and the corpus they are drawn from.
reported outcome	where it appears
immune modulation	Peptides Regulating Proliferative Activity and Inflammatory Pathways in the … International journal of molecular sciences 2022

Literature (8)

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line — International journal of molecular sciences 2022

This study evaluates the effects of five different peptides, the Epitalon® tetrapeptide, the Vilon® dipeptide, the Thymogen® dipeptide, the Thymalin® peptide complex, and the Chonluten® tripeptide, as regulators of inflammatory and proliferative processes in the human monocytic THP-1, which is a human leukemia monocytic cell line capable of differentiating into macrophages by PMA in vitro. These peptides (Khavinson Peptides®), characterized by Prof. Khavinson from 1973 onwards, were initially isolated from animal tissues and found to be organ specific. We tested the capacity of the five peptides to influence cell cultures in vitro by incubating THP-1 cells with peptides at certain concentrations known for being effective on recipient cells in culture. We found that all five peptides can modulate key proliferative patterns, increasing tyrosine phosphorylation of mitogen-activated cytoplas…

open access ↗ · PMID 35408963 · DOI 10.3390/ijms23073607

[KE peptide regulates SIRT1, PARP1, PARP2 gene expression and protein synthesis in human mesenchymal stem cells aging.] — Advances in gerontology = Uspekhi gerontologii 2023