database / longevity

Pinealon

also known as EDR peptide

preclinical longevity nervous no independent mass to check against

Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.

Sequence

EDR

Glu-Asp-Arg

hydrophobic
positive
negative
polar
aromatic
glycine
proline
cysteine

No independent molecular weight was available to check the sequence against.

Molecular data

Chemical fields come from the PubChem compound record; computed values are derived from the sequence shown above.
molecular formula	not characterised
molecular weight	418.41 Da (computed from sequence)
computed backbone mass	418.41 Da
length	3 residues
net charge (pH 7.4)	-1
mean hydropathy	-3.83
half-life	not characterised
delivery route	not characterised
PubChem CID	not characterised
PDB	not characterised
UniProt parent	not characterised

Mechanism

Short regulatory peptide from the Khavinson series studied in neuronal models.

Reported targets: not established

Experimental structure

No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.

Reported effects

Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.

Reported observations and the corpus they are drawn from.
reported outcome	where it appears
neuroprotection in models	Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future D… Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2026

Literature (8)

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions — Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2026

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influence over tissue regeneration, inflammation resolution, and neuromuscular recovery. Wound-healing peptides such as BPC-157, TB-500, and GHK-Cu promote angiogenesis, integrin-mediated extracellular matrix remodeling, and fibroblast activation, whereas growth hormone secretagogues like ipamorelin, CJC-1295, tesamorelin, sermorelin, and AOD-9604 activate IGF-1 signaling and satellite cell repair. Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived n…

open access ↗ · PMID 41490200 · DOI 10.5435/jaaosglobal-d-25-00236

Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes — Rejuvenation research 2011