database / immune
Vancomycin
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 14969. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
Primary structure not characterised in the public records this index draws on. Nothing is shown rather than something invented.
A glycopeptide assembled non-ribosomally; its cross-linked aromatic core is not a linear peptide sequence.
Molecular data
| molecular formula | C66H75Cl2N9O24 |
|---|---|
| molecular weight | 1449.2 Da (PubChem) |
| computed backbone mass | not characterised |
| length | not characterised |
| net charge (pH 7.4) | not characterised |
| mean hydropathy | not characterised |
| half-life | not characterised |
| delivery route | intravenous, oral |
| PubChem CID | 14969 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Binds the D-Ala-D-Ala terminus of peptidoglycan precursors, blocking cell-wall cross-linking.
Reported targets: peptidoglycan D-Ala-D-Ala
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| bactericidal activity against Gram-positive organisms | Discrepancies in Vancomycin Clearance Estimation Among Renal Function Models… Basic & clinical pharmacology & toxicology 2026 |
Registered trials
| NCT | title | status | phase |
|---|---|---|---|
| NCT00991185 | Cerebrospinal Fluid (CSF) Pharmacokinetics of Antimicrobials in Children | COMPLETED | — |
| NCT00295178 | Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipe | COMPLETED | PHASE4 |
| NCT03268122 | Comparison of Standard Isolation With Targeted Isolation for Preventing Nosocomial Transmiss | COMPLETED | NA |
| NCT01496794 | Endophthalmitis Cultures | TERMINATED | — |
| NCT06272994 | Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin | COMPLETED | NA |
Literature (8)
Discrepancies in Vancomycin Clearance Estimation Among Renal Function Models in Patients With Low Serum Creatinine Levels: A Pilot Study — Basic & clinical pharmacology & toxicology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42609167 · DOI 10.1111/bcpt.70287
Acute Kidney Injury During Vancomycin Treatment in Adult Patients With Haematologic Malignancies: A Multicentre Retrospective Study — Basic & clinical pharmacology & toxicology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42633950 · DOI 10.1111/bcpt.70297
Assessing Vancomycin-Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry — Chembiochem : a European journal of chemical biology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42555848 · DOI 10.1002/cbic.70495
Evaluation of Vancomycin Dosing Practices in Critically Ill Patients Receiving Accelerated Venovenous Hemofiltration — Journal of clinical pharmacology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42212507 · DOI 10.1002/jcph.70176
Vancomycin-stressed <i>Staphylococcus aureus</i> extracellular vesicles hijack macrophage autophagy to enhance bacterial intracellular survival — Autophagy 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42437365 · DOI 10.1080/15548627.2026.2702841
Narasin used as a feed additive in conventional rearing of broilers can co-select for vancomycin-resistant Enterococcus faecium through the NarAB ionophore resistance mechanisms — The Journal of antimicrobial chemotherapy 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42639740 · DOI 10.1093/jac/dkag253
Vancomycin-Mediated Binding of DNA Origami Nanostructures to Gram-Positive and Gram-Negative Bacteria — Chembiochem : a European journal of chemical biology 2026
DNA origami nanostructures (DONs) have promising applications in biomedicine and biosensing, which often require their efficient binding to target cells. By immobilizing the glycopeptide antibiotic vancomycin on DONs, DON binding to Gram-positive and Gram-negative bacteria can be facilitated. Here, we investigate how this multivalent binding is affected by the number and arrangement of the vancomycin modifications on two-dimensional DONs. We find that for both Gram-positive Bacillus subtilis and Gram-negative Escherichia coli, binding increases with the number of vancomycin modifications per DON. In general, binding to E. coli is stronger than to B. subtilis, which may be attributed to differences in the architectures of the cell envelopes. Interestingly, for both bacteria, the total number of vancomycin modifications appears to be more important than their arrangement, as DONs with 18 v…
open access ↗ · PMID 42376742 · DOI 10.1002/cbic.70436
The efflux pump QacA mediates the transition to vancomycin heteroresistance in sequence type 5 methicillin-resistant <i>Staphylococcus aureus</i> via membrane lipid reprogramming — Emerging microbes & infections 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42504701 · DOI 10.1080/22221751.2026.2698241
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