database / cosmetic
Acetyl octapeptide-3
also known as SNAP-8
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 76283482. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
EEMQRRAD
Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp
- hydrophobic
- positive
- negative
- polar
- aromatic
- glycine
- proline
- cysteine
Modified molecule. N-acetylated, C-terminal amide; an elongated Argireline analogue.
Backbone carries modifications, so computed backbone mass is not comparable to the reported mass of the complete molecule.
Molecular data
| molecular formula | C41H70N16O16S |
|---|---|
| molecular weight | 1075.2 Da (PubChem) |
| computed backbone mass | 1034.11 Da |
| length | 8 residues |
| net charge (pH 7.4) | -1 |
| mean hydropathy | -2.41 |
| half-life | not characterised |
| delivery route | topical |
| PubChem CID | 76283482 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
SNAP-25 N-terminal mimetic.
Reported targets: SNARE complex
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| expression-line softening | Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Ha… Annals of dermatology 2024 |
Literature (2)
Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities — Annals of dermatology 2024
BackgroundAnti-aging products are widely used, but the desire for safe and more efficient anti-aging products continues to increase. Dissolving microneedle patches (MNPs) have provided a more efficient transdermal drug delivery solution. MNP is a promising candidate for developing better anti-aging products.ObjectiveTo develop a more efficient anti-aging MNP product, we fabricated a dual anti-wrinkle microneedle patch (named DA-MNP) using droplet extension (DEN®) technology and evaluated its skin puncture ability, safety, and efficacy through clinical studies.MethodsA DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology. Placebo MNPs comprising only HA were also fabricated. Twenty-four healthy subjects were enrolled in this comparative clinical study. The…
open access ↗ · PMID 39082657 · DOI 10.5021/ad.23.136
Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study — Journal of cosmetic dermatology 2020
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 31134751 · DOI 10.1111/jocd.13009
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