database / cosmetic
Palmitoyl tetrapeptide-7
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 10078408. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
GQPR
Gly-Gln-Pro-Arg
- hydrophobic
- positive
- negative
- polar
- aromatic
- glycine
- proline
- cysteine
Modified molecule. Palmitoylated tetrapeptide; frequently paired with palmitoyl tripeptide-1 in formulation.
Backbone carries modifications, so computed backbone mass is not comparable to the reported mass of the complete molecule.
Molecular data
| molecular formula | C34H62N8O7 |
|---|---|
| molecular weight | 694.9 Da (PubChem) |
| computed backbone mass | 456.5 Da |
| length | 4 residues |
| net charge (pH 7.4) | +1 |
| mean hydropathy | -2.5 |
| half-life | not characterised |
| delivery route | topical |
| PubChem CID | 10078408 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Studied for effects on interleukin signalling in skin models.
Reported targets: dermal fibroblasts
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| inflammatory-marker reduction in skin models | Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid ge… International journal of biological macromolecules 2025 |
Literature (4)
Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing — International journal of biological macromolecules 2025
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 40023432 · DOI 10.1016/j.ijbiomac.2025.141578
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream — Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024
BackgroundThe delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.AimTo evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).MethodsThe cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, …
open access ↗ · PMID 38932444 · DOI 10.1111/srt.13790
Usage of Synthetic Peptides in Cosmetics for Sensitive Skin — Pharmaceuticals (Basel, Switzerland) 2021
Sensitive skin is characterized by symptoms of discomfort when exposed to environmental factors. Peptides are used in cosmetics for sensitive skin and stand out as active ingredients for their ability to interact with skin cells by multiple mechanisms, high potency at low dosage and the ability to penetrate the stratum corneum. This study aimed to analyze the composition of 88 facial cosmetics for sensitive skin from multinational brands regarding usage of peptides, reviewing their synthetic pathways and the scientific evidence that supports their efficacy. Peptides were found in 17% of the products analyzed, namely: acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-8, acetyl tetrapeptide-15, palmitoyl tripeptide-5, acetyl hexapeptide-49, palmitoyl tetrapeptide-7 and palmitoyl oligopeptide. Three out of seven peptides have a neurotransmitter-inhibiting mechanism of action, while anoth…
open access ↗ · PMID 34451799 · DOI 10.3390/ph14080702
Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications — Journal of cosmetic dermatology 2015
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 25817264 · DOI 10.1111/jocd.12135
Related
GHK-Cu
cosmetic · 8 citations
Palmitoyl pentapeptide-4
cosmetic · 8 citations
Acetyl hexapeptide-8
cosmetic · 8 citations
Acetyl octapeptide-3
cosmetic · 2 citations
Palmitoyl tripeptide-1
cosmetic · 5 citations