database / cosmetic
Acetyl hexapeptide-8
also known as Argireline, acetyl hexapeptide-3
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 71587772. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
EEMQRR
Glu-Glu-Met-Gln-Arg-Arg
- hydrophobic
- positive
- negative
- polar
- aromatic
- glycine
- proline
- cysteine
Modified molecule. N-acetylated, C-terminal amide. Mimics the N-terminal end of SNAP-25.
Backbone carries modifications, so computed backbone mass is not comparable to the reported mass of the complete molecule.
Molecular data
| molecular formula | C35H62N14O11S |
|---|---|
| molecular weight | 887 Da (PubChem) |
| computed backbone mass | 847.94 Da |
| length | 6 residues |
| net charge (pH 7.4) | 0 |
| mean hydropathy | -2.93 |
| half-life | not characterised |
| delivery route | topical |
| PubChem CID | 71587772 |
| PDB | not characterised |
| UniProt parent | P60880 |
Mechanism
SNAP-25 mimetic studied for interference with SNARE complex assembly in vitro.
Reported targets: SNARE complex
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Position in the parent protein
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKD…
Parent sequence from UniProt P60880. Sequence mimics the SNAP-25 N-terminus.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| expression-line softening | Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis JMIR dermatology 2024 |
Literature (8)
Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis — JMIR dermatology 2024
BackgroundAcetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide that has recently gained popularity for its antiwrinkle effects. This agent has emerged as a more accessible alternative to botulinum neurotoxin.ObjectiveThis study evaluates the public interest in acetyl hexapeptide-8 in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine.MethodsWe analyzed the longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, for acetyl hexapeptide-related terms. We compared the internet search trends for "Botox" during this period to "Argireline."ResultsThe terms "Argireline" and "Botox in a Bottle" both had substantial increases in search volume in 2022. Although its search volume is drastically increasing, "Argireline" was less searched than "Botox," which had a stable, up-tr…
open access ↗ · PMID 38376906 · DOI 10.2196/54217
Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics — International journal of toxicology 2025
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 40673537 · DOI 10.1177/10915818251340391
Ex Vivo Evaluation of Skin Permeability Enhancement Using TargetCool in Human-Derived Skin Tissue Models — The Journal of craniofacial surgery 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42084412 · DOI 10.1097/scs.0000000000012829
BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model — Journal of cosmetic dermatology 2025
BackgroundBakuchiol (BAK) and acetyl hexapeptide-8 have favorable biological activities and have promising applications in the cosmetic industry. However, the evaluation of the biological activity of both alone or in combination has not been reported.AimsThe biological activity of both alone or in combination was evaluated based on the zebrafish model.MethodsZebrafish embryos were induced to form models using different methods. Add BAK and Argireline YOUth peptide oil solution MB (ARG, containing 0.125% acetyl hexapeptide-8) to treat zebrafish embryos, and they were evaluated for their restorative effects on preexisting damage in zebrafish embryos.ResultsBAK and ARG were able to reduce water loss from the caudal fin of zebrafish induced by 0.9% NaCl solution. They were able to alleviate the UVB-induced decrease in the expression level of the skin tightness-related gene (ELN/COL1a1b) in z…
open access ↗ · PMID 40176351 · DOI 10.1111/jocd.70128
Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization — Journal of cutaneous and aesthetic surgery 2023
IntroductionWe propose a new facial lifting protocol using polydioxanone (PDO) threads embedded in acetyl hexapeptide-8 (Argireline [Arg]). We assume that Arg reinforces the effects of PDO threads, as it is a mimetic of botulinum toxin. Because the PDO suture is hydrolyzable, this assumption is analyzed by instrumental analysis.ObjectiveTo demonstrate the capacity of the PDO suture as a system for the controlled release of acetyl hexapeptide-8 to apply in deep wrinkles of the upper third.Materials and methodsThree segments of 1-cm long 21G PDO threads immersed in 1 mL of Arg. PDO threads were observed under an optical, electron microscope at 24, 48, and 72 h later. They were also weighed before and after being soaked in Arg, and employing ultraviolet (UV)-visible spectroscopy, the release rate of Arg from the PDO suture was measured. Finally, was insert the thread PDO-Arg following a pro…
open access ↗ · PMID 38314369 · DOI 10.4103/jcas.jcas_34_23
Acetyl Hexapeptide-8 as a Topical Alternative to Botulinum Toxin: A Review of the Literature — Journal of drugs in dermatology : JDD 2025
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 40196949
The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies — International journal of cosmetic science 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 41668671 · DOI 10.1111/ics.70087
Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy — International journal of molecular sciences 2025
Biomimetic peptides represent a growing class of active ingredients in modern cosmeceuticals, designed to mimic the function of the naturally occurring peptides involved in skin homeostasis, repair, and regeneration. Among them, acetyl hexapeptide-8 (AH-8), often referred to as a "botox-like" peptide, has received considerable attention for its potential to dynamically reduce wrinkles through the modulation of neuromuscular activity. AH-8 is widely used in topical formulations intended for anti-aging effects, scar treatment, and skin rejuvenation. This review provides a comprehensive overview of the structure and proposed mechanisms of action of AH-8, with particular focus on its efficacy and skin penetration properties. Due to its hydrophilic nature and relatively large molecular size, AH-8 faces limited permeability through the lipophilic stratum corneum, making effective dermal delive…
open access ↗ · PMID 40565185 · DOI 10.3390/ijms26125722
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