database / cosmetic
Palmitoyl tripeptide-1
also known as pal-GHK
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 10231864. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
GHK
Gly-His-Lys
- hydrophobic
- positive
- negative
- polar
- aromatic
- glycine
- proline
- cysteine
Modified molecule. Palmitoylated GHK for topical delivery.
Backbone carries modifications, so computed backbone mass is not comparable to the reported mass of the complete molecule.
Molecular data
| molecular formula | C30H54N6O5 |
|---|---|
| molecular weight | 578.8 Da (PubChem) |
| computed backbone mass | 340.38 Da |
| length | 3 residues |
| net charge (pH 7.4) | +1 |
| mean hydropathy | -2.5 |
| half-life | not characterised |
| delivery route | topical |
| PubChem CID | 10231864 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Matrikine-derived signal peptide used in matrix-support formulations.
Reported targets: dermal fibroblasts
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| collagen synthesis | EGCG-Biotin-Pal-GHK composition modulates TGF-β and BMP pathways in scalp mi… European journal of pharmacology 2026 |
| skin firmness | Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and p… BioImpacts : BI 2025 |
Literature (5)
EGCG-Biotin-Pal-GHK composition modulates TGF-β and BMP pathways in scalp microenvironment for treating stress-induced alopecia — European journal of pharmacology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42575238 · DOI 10.1016/j.ejphar.2026.179217
Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective — BioImpacts : BI 2025
IntroductionPeptides are promising and attractive anti-wrinkle active ingredients, amongst which glycyl-histidyl-lysine peptide (GHK) is one of the most broadly promoted peptide for topical application. This simple sequence of amino acid residues not only has the capability of tissue regeneration and the enhancement of collagen and glycosaminoglycans synthesis but also is able to increase nerve outgrowth and angiogenesis. Consequently, GHK has several properties, from wound healing to prevention/reduction wrinkles. GHK-Cu and Pal-GHK are metal complex and palmitoylated derivatives of GHK, respectively. Although GHK-Cu and Pal-GHK are widely used in anti-wrinkle products available on the cosmetic market, the published information on their skin permeability, effectiveness, physicochemical properties and so on is insufficient.MethodsThis review aims to highlight whether GHK is sufficiently …
open access ↗ · PMID 39963574 · DOI 10.34172/bi.30071
Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism — Journal of cosmetic dermatology 2026
BackgroundCollagen is essential for maintaining skin structure and function, and the circadian rhythm is known to regulate a wide range of physiological processes.AimsTo investigate whether collagen metabolism in human skin fibroblasts exhibits circadian regulation, and to evaluate whether the time-coordinated application of baicalin at daytime and palmitoyl tripeptide-1 (PT-1) at nighttime synergistically promotes collagen fiber formation and improves overall skin quality.MethodsA circadian-synchronized human skin fibroblast model was established. The expression of collagen metabolism-related genes was analyzed using qPCR and immunofluorescence. Subsequently, an 8-week topical application study was conducted in mice using a regimen of daytime baicalin and nighttime PT-1. Finally, a clinical trial involving 30 female participants was conducted, employing the same time-coordinated applica…
open access ↗ · PMID 41527525 · DOI 10.1111/jocd.70638
Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines — Biochemical and biophysical research communications 2025
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 39632290 · DOI 10.1016/j.bbrc.2024.151060
Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics — Analytica chimica acta 2009
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 19393372 · DOI 10.1016/j.aca.2009.03.015
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