database / nootropic

Selank

preclinical nootropic nervousimmune mass-verified

53 heavy atoms · 112 bonds · drag to pan, scroll to zoom C33N11O9

Skeletal structure drawn from the computed atomic coordinates in PubChem CID 11765600. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.

Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.

Sequence

TKPRPGP

Thr-Lys-Pro-Arg-Pro-Gly-Pro

hydrophobic
positive
negative
polar
aromatic
glycine
proline
cysteine

Computed backbone mass 751.88 Da agrees with PubChem's reported 751.9 Da (Δ 0.02 Da). Two independent sources agree on the primary structure.

Molecular data

Chemical fields come from the PubChem compound record; computed values are derived from the sequence shown above.
molecular formula	C33H57N11O9
molecular weight	751.9 Da (PubChem)
computed backbone mass	751.88 Da
length	7 residues
net charge (pH 7.4)	+2
mean hydropathy	-2.04
half-life	not characterised
delivery route	intranasal
PubChem CID	11765600
PDB	not characterised
UniProt parent	not characterised

Mechanism

Tuftsin analogue (Thr-Lys-Pro-Arg) extended with Pro-Gly-Pro; studied for anxiolytic-like activity in animal models.

Reported targets: GABAergic and tuftsin pathways

Experimental structure

No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.

Reported effects

Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.

Reported observations and the corpus they are drawn from.
reported outcome	where it appears
anxiolytic-like activity in models	Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future D… Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2026
BDNF expression in models	Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine W… Bulletin of experimental biology and medicine 2022

Registered trials

Records from ClinicalTrials.gov. Listed for reference — this project sponsors no trial and is not involved in any of them.
NCT	title	status	phase
NCT06151093	The Effect of Balance Exercises on Cognitive Function	COMPLETED	NA
NCT05076045	Effects of PSAPs on Speech Processing	COMPLETED	NA
NCT07196085	Neural Mechanisms and Efficacy of Imagery Rescripting for Fear of Failure	COMPLETED	NA
NCT05832060	Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescent	UNKNOWN	NA
NCT01747200	Effects of Transcranial Magnetic Stimulation on Object Recognition	COMPLETED	NA

Literature (8)

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions — Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2026

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influence over tissue regeneration, inflammation resolution, and neuromuscular recovery. Wound-healing peptides such as BPC-157, TB-500, and GHK-Cu promote angiogenesis, integrin-mediated extracellular matrix remodeling, and fibroblast activation, whereas growth hormone secretagogues like ipamorelin, CJC-1295, tesamorelin, sermorelin, and AOD-9604 activate IGF-1 signaling and satellite cell repair. Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived n…

open access ↗ · PMID 41490200 · DOI 10.5435/jaaosglobal-d-25-00236

Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats — Bulletin of experimental biology and medicine 2022