database / nootropic
Cerebrolysin
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
Primary structure not characterised in the public records this index draws on. Nothing is shown rather than something invented.
A porcine brain-derived peptide mixture, not a single defined molecule — no sequence exists to report.
Molecular data
| molecular formula | not characterised |
|---|---|
| molecular weight | not characterised |
| computed backbone mass | not characterised |
| length | not characterised |
| net charge (pH 7.4) | not characterised |
| mean hydropathy | not characterised |
| half-life | not characterised |
| delivery route | intravenous, intramuscular |
| PubChem CID | not characterised |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Peptide preparation studied for neurotrophic-like activity.
Reported targets: not established
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| cognitive outcomes in trials | Very Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Throm… Case reports in neurological medicine 2026 |
| stroke-recovery outcomes in trials | Adjunctive Cerebrolysin therapy following mechanical thrombectomy for acute … Journal of medicine and life 2026 |
Registered trials
| NCT | title | status | phase |
|---|---|---|---|
| NCT05124353 | Early Administration of Cerebrolysin on the Outcome of Patients With Acute Stroke Undergoing | UNKNOWN | PHASE2, PHASE3 |
| NCT06897176 | Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A R | RECRUITING | PHASE4 |
| NCT06677502 | Cerebrolysin in Critically Ill Patients With Delirium | ENROLLING_BY_INVITATION | NA |
| NCT06273020 | Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Str | UNKNOWN | PHASE4 |
| NCT01787123 | Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cer | COMPLETED | PHASE2, PHASE3 |
Literature (8)
Very Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report — Case reports in neurological medicine 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42666484 · DOI 10.1155/crnm/9962315
Adjunctive Cerebrolysin therapy following mechanical thrombectomy for acute basilar artery occlusion: a case report — Journal of medicine and life 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42602665 · DOI 10.25122/jml-2026-0081
ABSTRACT NUMBER: ESOC2026A822 VIRTUAL REALITY NEURORREHABILITATION IN ACUTE STROKE PATIENTS AND THE ADD-ON EFFECT OF CEREBROLYSIN — European stroke journal 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
Cerebrolysin as an adjunct to speech-language therapy in post-stroke Wernicke's aphasia: a case report — Journal of medicine and life 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42602663 · DOI 10.25122/jml-2026-0057
ABSTRACT NUMBER: ESOC2026A562 CEREBROLYSIN AFTER ENDOVASCULAR THROMBECTOMY IN STROKE: 12-MONTH FUNCTIONAL OUTCOMES IN A PROPENSITY-MATCHED COHORT — European stroke journal 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
ABSTRACT NUMBER: ESOC2026A632 CYTOPROTECTIVE EFFICACY OF CEREBROLYSIN IN PATIENTS WITH RESIDUAL POST-THROMBECTOMY PERFUSION DEFICITS: A PROOF-OF-CONCEPT STUDY — European stroke journal 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
ABSTRACT NUMBER: ESOC2026A102 META-ANALYSIS: THE EFFECT OF CEREBROLYSIN COMBINED WITH SPEECH THERAPY ON NONFLUENT APHASIA RECOVERY AFTER ISCHEMIC STROKE — European stroke journal 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
Exosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability — Cells 2026
Cerebrolysin has a salutary effect on impaired cerebral endothelial cell (CEC) permeability. Using an in vitro endothelial permeability assay, the present study tested the hypothesis that exosomes released by Cerebrolysin-treated CECs (Cerebro-Exos) have a robust therapeutic effect on dysfunctional CECs. Stoichiometric analysis showed marked differences in cargo profiles between Cerebro-Exos and exosomes derived from CECs without Cerebrolysin treatment (Naïve-Exos), in which Cerebro-Exos were highly enriched with metabolic and tight junction related proteins compared to Naïve-Exos. Cerebro-Exos had a superior effect compared to Naïve-Exos on restoring CEC integrity impaired by fibrin and tissue plasminogen activator (tPA). Treatment of fibrin- and tPA-challenged CECs with Cerebro-Exos robustly reduced fibrin- and tPA-augmented proteins involved in inflammation and coagulation and substan…
open access ↗ · PMID 42193943 · DOI 10.3390/cells15100934