database / nootropic
DSIP
also known as delta sleep-inducing peptide
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 68816. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
WAGGDASGE
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- hydrophobic
- positive
- negative
- polar
- aromatic
- glycine
- proline
- cysteine
Computed backbone mass 848.82 Da agrees with PubChem's reported 848.8 Da (Δ 0.02 Da). Two independent sources agree on the primary structure.
Molecular data
| molecular formula | C35H48N10O15 |
|---|---|
| molecular weight | 848.8 Da (PubChem) |
| computed backbone mass | 848.82 Da |
| length | 9 residues |
| net charge (pH 7.4) | -2 |
| mean hydropathy | -0.7 |
| half-life | not characterised |
| delivery route | not characterised |
| PubChem CID | 68816 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Nonapeptide originally isolated from rabbit cerebral venous blood during induced sleep; mechanism not established.
Reported targets: not established
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| sleep architecture effects in models | <i>Pichia pastoris</i> secreted peptides crossing the blood-brain barrier an… Frontiers in pharmacology 2024 |
| stress-response modulation in models | Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future D… Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2026 |
Literature (8)
<i>Pichia pastoris</i> secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models — Frontiers in pharmacology 2024
BackgroundPichia pastoris-secreted delta sleep inducing peptide and crossing the blood-brain barrier peptides (DSIP-CBBBP) fusion peptides holds significant promise for its potential sleep-enhancing and neurotransmitter balancing effects. This study investigates these properties using a p-chlorophenylalanine (PCPA) -induced insomnia model in mice, an approach akin to traditional methods evaluating sleep-promoting activities in fusion peptides.Aim of the studyThe research aims to elucidate the sleep-promoting mechanism of DSIP-CBBBP, exploring its impact on neurotransmitter levels and sleep regulation, and to analyze its composition and structure.Materials and methodsUsing a PCPA-induced insomnia mouse model, the study evaluates the sleep-promoting effects of DSIP-CBBBP. The peptide's influence on neurotransmitters such as 5-HT, glutamate, dopamine, and melatonin is assessed. The function…
open access ↗ · PMID 39444618 · DOI 10.3389/fphar.2024.1439536
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions — Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2026
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influence over tissue regeneration, inflammation resolution, and neuromuscular recovery. Wound-healing peptides such as BPC-157, TB-500, and GHK-Cu promote angiogenesis, integrin-mediated extracellular matrix remodeling, and fibroblast activation, whereas growth hormone secretagogues like ipamorelin, CJC-1295, tesamorelin, sermorelin, and AOD-9604 activate IGF-1 signaling and satellite cell repair. Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived n…
open access ↗ · PMID 41490200 · DOI 10.5435/jaaosglobal-d-25-00236
Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke — Molecules (Basel, Switzerland) 2021
Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose [dose redacted]. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was…
open access ↗ · PMID 34500605 · DOI 10.3390/molecules26175173
Sensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in <i>Escherichia coli</i> — ACS omega 2024
The mode of action of antibiotics can be broadly classified as bacteriostatic and bactericidal. The bacteriostatic mode leads to the arrested growth of the cells, while the bacteriocidal mode causes cell death. In this work, we report the applicability of deuterium stable isotope probing (DSIP) in combination with Raman spectroscopy (Raman DSIP) for discriminating the mode of action of antibiotics at the community level. Escherichia coli, a well-known model microbe, was used as an organism for the study. We optimized the concentration of deuterium oxide required for metabolic activity monitoring without compromising the microbial growth. Our findings suggest that changes in the intensity of the C-D band in the high-wavenumber region could serve as a quantifiable marker for determining the antibiotic mode of action. This can be used for early identification of the antibiotic's mode of act…
open access ↗ · PMID 38854576 · DOI 10.1021/acsomega.4c01666
A federated policy-governed architecture for sovereign European data spaces — Open Res Europe 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · DOI 10.12688/openreseurope.24687.1
Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude — Life sciences 2018
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 30107169 · DOI 10.1016/j.lfs.2018.08.026
Sensing the bactericidal and bacteriostatic antimicrobial mode of action using Raman-Deuterium stable isotope probing (DSIP) — bioRxiv 2024
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · DOI 10.1101/2024.02.12.579891
Delta-sleep inducing peptide entrapment in the charged macroporous matrices — Materials science & engineering. C, Materials for biological applications 2014
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 25063142 · DOI 10.1016/j.msec.2014.05.059