Melittin

preclinical immune immune modified — mass check n/a

201 heavy atoms · 432 bonds · drag to pan, scroll to zoom C131N39O31

Skeletal structure drawn from the computed atomic coordinates in PubChem CID 16133648. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.

Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.

Sequence

GIGAVLKVLTTGLPALISWIKRKRQQ

Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln

hydrophobic
positive
negative
polar
aromatic
glycine
proline
cysteine

Modified molecule. C-terminal amide.

Backbone carries modifications, so computed backbone mass is not comparable to the reported mass of the complete molecule.

Molecular data

Chemical fields come from the PubChem compound record; computed values are derived from the sequence shown above.
molecular formula	C131H229N39O31
molecular weight	2846.5 Da (PubChem)
computed backbone mass	2847.49 Da
length	26 residues
net charge (pH 7.4)	+5
mean hydropathy	0.27
half-life	not characterised
delivery route	not characterised
PubChem CID	16133648
PDB	2MLT
UniProt parent	not characterised

Mechanism

Amphipathic membrane-lytic peptide from honeybee venom; a standard model of pore formation.

Reported targets: lipid bilayers

Experimental structure

α-carbon backbone trace rendered from the deposited coordinates of PDB 2MLT. This is measured structure, not a prediction.

Helical wheel

Residues projected at 100° per turn, the standard α-helix rotation. Shown because helicity in this peptide is described in the cited literature.

Reported effects

Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.

Reported observations and the corpus they are drawn from.
reported outcome	where it appears
membrane lysis	Melittin- and Apamin-Standardized Bee Venom: UHPLC-ESI-MS Characterization, … Molecules (Basel, Switzerland) 2026
antimicrobial activity	Optimizing separation conditions for melittin purification from bee venom us… Biophysical chemistry 2026
anti-tumour activity in models	Melittin intervention induces lncRNA response, mitochondrial dysfunction, an… bioRxiv 2026

Literature (8)

Melittin- and Apamin-Standardized Bee Venom: UHPLC-ESI-MS Characterization, Antibacterial Activity, and Apoptosis Induction in Human Keratinocytes — Molecules (Basel, Switzerland) 2026