database / immune
Magainin 2
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
GIGKFLHSAKKFGKAFVGEIMNS
Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser
- hydrophobic
- positive
- negative
- polar
- aromatic
- glycine
- proline
- cysteine
No independent molecular weight was available to check the sequence against.
Molecular data
| molecular formula | not characterised |
|---|---|
| molecular weight | 2466.93 Da (computed from sequence) |
| computed backbone mass | 2466.93 Da |
| length | 23 residues |
| net charge (pH 7.4) | +3 |
| mean hydropathy | 0.08 |
| half-life | not characterised |
| delivery route | not characterised |
| PubChem CID | not characterised |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Amphipathic antimicrobial peptide from frog skin; permeabilises microbial membranes.
Reported targets: microbial membranes
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Helical wheel
Residues projected at 100° per turn, the standard α-helix rotation. Shown because helicity in this peptide is described in the cited literature.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| antimicrobial activity | Charge-dependent insertion of the antimicrobial peptide magainin 2 into lipi… Biochimica et biophysica acta. Biomembranes 2026 |
| membrane permeabilisation | Unveiling the Potential of Magainin Derivatives against Candida Species Journal of medicinal chemistry 2026 |
Literature (8)
Charge-dependent insertion of the antimicrobial peptide magainin 2 into lipid monolayers probed by neutron reflectivity — Biochimica et biophysica acta. Biomembranes 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42501887 · DOI 10.1016/j.bbamem.2026.184563
Unveiling the Potential of Magainin Derivatives against Candida Species — Journal of medicinal chemistry 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42593921 · DOI 10.1021/acs.jmedchem.6c01330
Aromatic Fluorination Enhances the Hydrophobicity and Antimicrobial Activity of Magainin 2 — ACS applied materials & interfaces 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42587486 · DOI 10.1021/acsami.6c07776
Magainin II- and CWR11-Functionalized Stainless-Steel Surfaces for Reducing Bacterial Survival, Attachment, Biofilm Formation, and Transfer on Public Western-Style Toilet Hardware — Research Square 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · DOI 10.21203/rs.3.rs-10577304/v1
Computational examination of magainin-I-KL mediated disruption of E. coli biofilms via CsgA amyloid interference — Archives of microbiology 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 41724836 · DOI 10.1007/s00203-026-04797-7
Evidence of curvature bias and local POPG recruitment during surface-bound interactions of a cationic peptide with POPC/POPG membrane — Journal of biomolecular structure & dynamics 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 42647096 · DOI 10.1080/07391102.2026.2723202
PGLa and Magainin 2 Can Porate Membranes via Transient Hourglass-Shaped Toroidal Pores — Journal of the American Chemical Society 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 41486758 · DOI 10.1021/jacs.5c11101
Structural and mechanistic divergence in LL-37, HNP-1, and Magainin-2: An integrated computational and biophysical analysis — Current research in structural biology 2025
Escalating antimicrobial resistance necessitates the development of alternative therapeutics that circumvent conventional enzymatic and efflux-based defence systems. Antimicrobial peptides (AMPs) represent a compelling class of innate immune effectors, however, their clinical translation is hindered by incomplete mechanistic understanding of how structural organization and conformational dynamics shape antimicrobial function. In this study, we performed an integrated comparative analysis of three mechanistically representative AMPs-LL-37, HNP-1, and magainin-2-to resolve how maturation pathways, fold topology, amphipathic architecture, and dynamic target engagement govern antimicrobial action. Consensus secondary-structure prediction, AlphaFold2/PEP-FOLD modelling, and physicochemical profiling revealed three distinct structural signatures. LL-37 exhibited a flexible disorder-to-helix tr…
open access ↗ · PMID 41376844 · DOI 10.1016/j.crstbi.2025.100176
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