database / gh-secretagogue
IGF-1 LR3
also known as Long R3 IGF-1
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
Primary structure not characterised in the public records this index draws on. Nothing is shown rather than something invented.
An 83-residue analogue of insulin-like growth factor 1 with an Arg3 substitution and a 13-residue N-terminal extension — a protein-scale construct, not transcribed here.
Molecular data
| molecular formula | not characterised |
|---|---|
| molecular weight | not characterised |
| computed backbone mass | not characterised |
| length | not characterised |
| net charge (pH 7.4) | not characterised |
| mean hydropathy | not characterised |
| half-life | not characterised |
| delivery route | not characterised |
| PubChem CID | not characterised |
| PDB | not characterised |
| UniProt parent | P05019 |
Mechanism
IGF-1 analogue with reduced IGF-binding-protein affinity.
Reported targets: IGF1R
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Parent protein
Analogue of mature IGF-1. UniProt P05019 · 195 aa
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| anabolic signalling in models | Effect of recombinant porcine IGFBP-3 on IGF-I and long-R3-IGF-I-stimulated … Journal of cellular physiology 2004 |
Literature (8)
Effect of recombinant porcine IGFBP-3 on IGF-I and long-R3-IGF-I-stimulated proliferation and differentiation of L6 myogenic cells — Journal of cellular physiology 2004
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 15254966 · DOI 10.1002/jcp.20068
Effects of insulin-like growth factor-I and its analogue, long-R3-IGF-I, on intestinal absorption of 3-O-methyl-D-glucose are less pronounced than gut mucosal growth responses — Growth factors (Chur, Switzerland) 2002
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 11999215 · DOI 10.1080/08977190290022194
Production of recombinant porcine IGF-binding protein-5 and its effect on proliferation of porcine embryonic myoblast cultures in the presence and absence of IGF-I and Long-R3-IGF-I — The Journal of endocrinology 2005
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 15817840 · DOI 10.1677/joe.1.06037
Endocrine and metabolic changes in neonatal calves in response to growth hormone and long-R3-insulin-like growth factor-I administration — Biology of the neonate 1998
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 9483305 · DOI 10.1159/000013968
Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression — The Journal of endocrinology 2008
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 18577570 · DOI 10.1677/joe-07-0556
The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I — The American journal of physiology 1997
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 9252489 · DOI 10.1152/ajpendo.1997.273.1.e130
Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I — Experimental physiology 2000
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 10825414 · DOI 10.1111/j.1469-445x.2000.01973.x
Chemical treatment of Escherichia coli. II. Direct extraction of recombinant protein from cytoplasmic inclusion bodies in intact cells — Biotechnology and bioengineering 1998
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 10099214 · DOI 10.1002/(sici)1097-0290(19980220)57:4<381::aid-bit1>3.0.co;2-i
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