database / gh-secretagogue
GHRP-2
also known as pralmorelin
Skeletal structure drawn from the computed atomic coordinates in PubChem CID 6918245. Carbons are implicit vertices; hydrogens on carbon are suppressed, as in any structural formula. Nothing here is estimated — every atom sits where PubChem placed it.
Research reference only. The observations below are recorded in the cited literature. Nothing here is advice or a recommendation, and no dosing information is published on this site.
Sequence
Primary structure not characterised in the public records this index draws on. Nothing is shown rather than something invented.
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 — contains D-amino acids and 2-naphthylalanine.
Molecular data
| molecular formula | C45H55N9O6 |
|---|---|
| molecular weight | 818 Da (PubChem) |
| computed backbone mass | not characterised |
| length | not characterised |
| net charge (pH 7.4) | not characterised |
| mean hydropathy | not characterised |
| half-life | not characterised |
| delivery route | not characterised |
| PubChem CID | 6918245 |
| PDB | not characterised |
| UniProt parent | not characterised |
Mechanism
Synthetic ghrelin receptor agonist.
Reported targets: GHS-R1a
Experimental structure
No experimental structure of this peptide is deposited in the PDB. Nothing is rendered here — a predicted fold would not be a structure, and this site does not draw one.
Reported effects
Each row is an outcome described in the literature indexed for this peptide. Reported in the cited work — not a claim, not a recommendation.
| reported outcome | where it appears |
|---|---|
| GH release | Growth Hormone-Releasing Peptide 2 May Be Associated With Decreased M1 Macro… Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2025 |
| appetite stimulation | Unveiling the Role of Melatonin in Coronary Heart Disease: Identification an… Research Square 2026 |
Literature (8)
Growth Hormone-Releasing Peptide 2 May Be Associated With Decreased M1 Macrophage Production and Increased Histologic and Biomechanical Tendon-Bone Healing Properties in a Rat Rotator Cuff Tear Model — Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2025
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 39672241 · DOI 10.1016/j.arthro.2024.11.094
Unveiling the Role of Melatonin in Coronary Heart Disease: Identification and Experimental Validation of Novel Biomarkers — Research Square 2026
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · DOI 10.21203/rs.3.rs-8816168/v1
Benchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism — Diseases (Basel, Switzerland) 2025
Background/objectivesOur objective is to develop hormone-producing pituitary cells that can function in the same manner as the human body and provide more effective treatments than current hormone replacement therapy. We have already established a technique for generating hypothalamic-pituitary organoids using feeder-free human pluripotent stem cells (hPSCs) and demonstrated their effectiveness in vivo through transplantation into hypopituitary mouse models. To prospectively determine the upper limit of transplanting adenohypophyseal cells into humans, we investigated the human maximum secretion capacity of adrenocorticotropic hormone (ACTH) and growth hormone (GH).MethodsWe analyzed data from 28 patients with pituitary adenomas, among whom 16 evinced no abnormality of ACTH secretion and 12 showed no GH secretion on corticotropin-releasing hormone (CRH) and growth hormone-releasing hormo…
open access ↗ · PMID 40277822 · DOI 10.3390/diseases13040112
Assessment of anterior pituitary reserve capacity based on growth hormone response to growth hormone-releasing peptide-2 test in the elderly — Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2023
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 37295337 · DOI 10.1016/j.ghir.2023.101545
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration — Frontiers in endocrinology 2026
Performance-enhancing drugs (PEDs) marketed as "research compounds" include unregulated peptides intended to modulate the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis. The agents most commonly encountered in clinical practice and online self-administration protocols include growth hormone-releasing hormone (GHRH) analogues (e.g., sermorelin, tesamorelin, CJC-1295 with Drug Affinity Complex [DAC], CJC-1295 without DAC), growth hormone secretagogues (GHS; e.g., growth hormone-releasing peptide-2 (GHRP-2), growth hormone-releasing peptide-6 (GHRP-6), hexarelin, ipamorelin), the growth hormone (GH) fragment - AOD9604 (hGH 176-191), and insulin-like growth factor-1 (IGF-1) analogues (e.g., pegylated mechano growth factor (PEG-MGF), IGF-1 Long R3 (IGF-1 LR3)). Reported adverse effects span endocrine and metabolic disturbances (including prolactin and cortisol elevations, appetit…
open access ↗ · PMID 42395176 · DOI 10.3389/fendo.2026.1822475
Diurnal and Daily Variations in Growth Hormone and Growth Hormone Stimulation Test in Male Cynomolgus Monkeys — In vivo (Athens, Greece) 2026
Background/aimGrowth hormone (GH) secretion patterns differ across species. Humans exhibit a nocturnal surge, while rodents exhibit ultradian pulses. In cynomolgus monkeys, diurnal and daily variations and responsiveness to exogenous GH-releasing hormone (GHRH) remain insufficiently defined in non-clinical studies. This study aimed to characterize GH secretion patterns and evaluate responsiveness to exogenous GHRH in adult male cynomolgus monkeys for pituitary toxicity studies.Materials and methodsSerum from 10 animals was collected between 10:00 and 22:30 and again at 10:30 on the following day to evaluate diurnal variation. Serum from 10 additional animals was collected once daily between 9:00 and 10:00 across five days to evaluate daily variation. In the GH stimulation test, four animals received intravenous pralmorelin hydrochloride (as GHRH) and four received physiological saline be…
open access ↗ · PMID 41482410 · DOI 10.21873/invivo.14182
Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial — Drug testing and analysis 2019
abstract not reproduced — this record is not open-access, so it is linked rather than copied.
publisher record ↗ · PMID 30051972 · DOI 10.1002/dta.2467
Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors — PloS one 2022
IntroductionGrowth hormone (GH) deficiency (GHD) is often complicated by non-functioning pituitary tumors (NFPTs); however, its prevalence remains unclear because preoperative screening for GHD with provocative tests is not recommended. Accordingly, we attempted to clarify the characteristics of GHD in unoperated patients with NFPT.Materials and methodsWe retrospectively reviewed adult patients with non-functioning pituitary adenoma (NFPA) and Rathke's cyst who underwent preoperative GH-releasing peptide-2 (GHRP-2) tests from January 2013 to December 2016. We investigated the association between peak GH response to GHRP-2 and background characteristics.ResultsAmong 104 patients (85 NFPA and 19 Rathke's cysts), 45 (43%) presented severe GHD, as diagnosed using GHRP-2 tests. Body mass index (β = -0.210, P = 0.007), free thyroxine (β = 0.440, P ConclusionWe observed a negative synergistic e…
open access ↗ · PMID 35452483 · DOI 10.1371/journal.pone.0267324
Related
Ghrelin
hormone · 8 citations
Ipamorelin
gh-secretagogue · 8 citations
CJC-1295
gh-secretagogue · 8 citations
Sermorelin
gh-secretagogue · 8 citations
Tesamorelin
gh-secretagogue · 8 citations
GHRP-6
gh-secretagogue · 7 citations